HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178418361, compound → HCID 178520964, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Reactant | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol | HCID 178521066 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 178520964 | HCID 178520964 | — |
Reaction Steps
In Step 4, inosine derivative (IV') is subjected to reduction with hydrogen (H2) in an organic solvent over a palladium catalyst. This reduction proceeds with minimum substrate decomposition. This is followed by hydrolysis or ester exchange reaction, giving 2',3'-dideoxyinosine derivative (A').
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466793 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-0e3ac7150bca4135ac10fa91e89337db |
| Source note | uspto-grants-1995_11 |