Guanidine → HCID 22377214, compound

HRID 1291042Notes

Reaction equation

HRID 1291042 reaction equation
[NH2:1][C:2]([NH2:4])=[NH:3].[F:5][C:6]1[CH:15]=[C:14]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH3:21])[C:13]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:12][C:7]=1[C:8](OC)=[O:9]>>[NH2:3][C:2]([NH2:4])=[N:1][C:8](=[O:9])[C:7]1[CH:12]=[C:13]([S:22]([CH3:25])(=[O:24])=[O:23])[C:14]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH3:21])=[CH:15][C:6]=1[F:5]

Participants

3

Reactant 2

HCID 3520GuanidineHCID 57287153HCID 57287153, compound

Product 1

HCID 22377214HCID 22377214, compound

Procedure

In analogy to Example 1, by reaction of guanidine with methyl 2-fluoro-4-(2-methyl-1-imidazolyl) -5-methylsulfonylbenzoate [obtainable by reacting 2-fluoro-4-chloro-5-methylsulfonylbenzoic acid with 2-methylimidazole followed by esterification] , N-diaminomethylene-2-fluoro-4- (2-methyl-1-imidazolyl) -5-methylsulfonylbenzamide is obtained.

Sources & evidence

ORD record
ord-46b04f85877f457b82ac9af49ec5568c
Source dataset
uspto-grants-1998_05
Patent number
US05753680

Reaction notes

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