HCID 18919848, compound → HCID 18919847, compound

HRID 1291086Notes

Reaction equation

HRID 1291086 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 18919848HCID 18919848, compound

Product 1

HCID 18919847HCID 18919847, compoundYield 151.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.363 g (0.001 mol) of 1-benzyl-piperidin-4-yl 4-chloro-benzoate was dissolved in 30 ml of dioxan, filtered over a microfilter and treated with 10 ml of 0.1N HCI. The mixture was stirred for 2 hrs., the solvent was removed completely and the residue was dissolved in 40 ml of water and lyophilized. The lyophilizate was recrystallized from ether/ethanol. 0.278 g (74%) of 1-benzyl-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 207°-209°.

Workup

  1. filtrationfiltered over a microfilter
  2. additiontreated with 10 ml of 0.1N HCI
  3. custom, the solvent was removed completely
  4. dissolutionthe residue was dissolved in 40 ml of water
  5. customThe lyophilizate was recrystallized from ether/ethanol

Sources & evidence

ORD record
ord-4e33a0649e6e49d88804e728f62a23fc
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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