HCID 18919848, compound → HCID 18919847, compound

Participants

Reaction Steps

0.363 g (0.001 mol) of 1-benzyl-piperidin-4-yl 4-chloro-benzoate was dissolved in 30 ml of dioxan, filtered over a microfilter and treated with 10 ml of 0.1N HCI. The mixture was stirred for 2 hrs., the solvent was removed completely and the residue was dissolved in 40 ml of water and lyophilized. The lyophilizate was recrystallized from ether/ethanol. 0.278 g (74%) of 1-benzyl-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 207°-209°.

Provenance & Evidence