HCID 18919805, compound → HCID 18919804, compound

HRID 1291137Notes

Reaction equation

HRID 1291137 reaction equation
[C:1]([O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:23].[C:1]([O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[CH2:14][CH2:15]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 18919805HCID 18919805, compound

Product 1

HCID 18919804HCID 18919804, compoundYield 185.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.155 g (0.00047 mol) of 1-(2-chloro-benzyl)-piperidin-4-yl benzoate was dissolved in 14 ml of ether, filtered, diluted with 0.4 ml of methanol and treated with 4.7 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.16 g (93%) of 1-(2-chloro-benzyl)-piperidin-4-yl benzoate hydrochloride (1:1) was obtained as white crystals;

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.4 ml of methanol
  3. additiontreated with 4.7 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-bac220263ad64071ad4ddcd9172284c3
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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