HCID 18919750, compound → HCID 18919941, compound

HRID 1291139Notes

Reaction equation

HRID 1291139 reaction equation
[CH3:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:22].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 1

HCID 18919750HCID 18919750, compound

Product 1

HCID 18919941HCID 18919941, compoundYield 172.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.298 g (0.000867 mol) of 1-(2-chloro-benzyl)-piperidin-4-yl 4-methyl-benzoate was dissolved in 26 ml of ether, filtered, diluted with 0.8 ml of methanol and treated with 8 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.285 g (86%) of 1-(2-chloro-benzyl)-piperidin-4-yl 4-methyl-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 188°-190°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.8 ml of methanol
  3. additiontreated with 8 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-3007777684834f19b2068fcfc405a9c1
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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