HCID 18919896, compound → HCID 18919895, compound

HRID 1291141Notes

Reaction equation

HRID 1291141 reaction equation
[C:1]([O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=2)[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:23].[C:1]([O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[CH:18]=2)[CH2:14][CH2:15]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 18919896HCID 18919896, compound

Product 1

HCID 18919895HCID 18919895, compoundYield 181.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.165 g (0.0005 mol) of 1-(3-chloro-benzyl)-piperidin-4-yl benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.6 ml of methanol and treated with 5 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.166 g (90.6%) of 1-(3-chloro-benzyl)-piperidin-4-yl benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 227°-228°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.6 ml of methanol
  3. additiontreated with 5 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-bd3ce646904d441a808ecfecbc16d116
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

Loading…