反应详情

0.31 g (0.0015 mol) of 1-(4-methyl-benzyl)-piperidin-4-ol and 0.52 ml (0.00375 mol) of triethylamine were dissolved in 15 ml of toluene, treated with 0.25 ml (0.001875 mol) of p-toluoyl chloride and boiled at reflux for 18 hrs. The reaction mixture was concentrated and the residue was chromatographed over silica gel with ethyl acetate/hexane (1:4). 0.4 g (83%) of 1-(4-methyl-benzyl)-piperidin-4-yl 4-methyl-benzoate was obtained as yellow crystals; m.p. 66°-77°.

1. temperatureat reflux for 18 hrs
2. concentrationThe reaction mixture was concentrated
3. customthe residue was chromatographed over silica gel with ethyl acetate/hexane (1:4)