HCID 18919740, compound → HCID 18919932, compound

HRID 1291181Notes

Reaction equation

HRID 1291181 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 1

HCID 18919740HCID 18919740, compound

Product 1

HCID 18919932HCID 18919932, compoundYield 169.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.182 g (0.0005 mol) of 1-(4-chloro-benzyl)-piperidin-4-yl 4-chloro-benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.5 ml of methanol and treated with 5 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.17 g (85%) of 1-(4-chloro-benzyl)-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 235°-237°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.5 ml of methanol
  3. additiontreated with 5 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-3004880aa43546689aae55ac22ad03fd
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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