HCID 18919757, compound → HCID 18919906, compound

HRID 1291183Notes

Reaction equation

HRID 1291183 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:22].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 1

HCID 18919757HCID 18919757, compound

Product 1

HCID 18919906HCID 18919906, compoundYield 175.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.285 g (0.00082 mol) of 1-(4-chloro-benzyl)-piperidin-4-yl 4-fluoro-benzoate was dissolved in 25 ml of ether, filtered, diluted with 8.5 ml of methanol and treated with 8.2 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.277 g (88%) of 1-(4-chloro-benzyl)-piperidin-4-yl 4-fluoro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 214°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 8.5 ml of methanol
  3. additiontreated with 8.2 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-a0b9c558e25a4a799e97f4ccfd320667
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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