HCID 10493689, compound → HCID 53650742, compound

HRID 129130Notes

Reaction equation

HRID 129130 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12]([OH:14])[CH3:13])[CH2:11][O:10]1.[F:15][C:16]([F:34])([CH:31]([F:33])[F:32])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH:29]=[CH:28][NH:27][C:26]2=O)=[CH:21][CH:20]=1.FC1C=C(F)C=CC=1[C@]1(OC1)[C@H](N1C=CN(C2C=CC(OCC(F)(F)C(F)F)=CC=2)C1=O)C>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([O:14][C:26]2[N:25]([C:22]3[CH:21]=[CH:20][C:19]([O:18][CH2:17][C:16]([F:34])([F:15])[CH:31]([F:32])[F:33])=[CH:24][CH:23]=3)[CH:29]=[CH:28][N:27]=2)[CH3:13])[CH2:11][O:10]1

Participants

4

Reactant 3

HCID 10493689HCID 10493689, compoundHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 15285752HCID 15285752, compound

Product 1

HCID 53650742HCID 53650742, compoundYield 11.9%

Procedure

In the same manner as in Reference Example 5, starting from 0.50 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 0.72 g of 1-[4-(2,2,3,3-tetrafluoropropoxy) phenyl]-2(1H, 3H)-imidazolone, 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone (0.21 g) and 0.14 g of (2R)-2-(2,4-difluorophenyl)-2-[(1R)-1-[1-(4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2-imidazolyloxy]ethyl]oxirane were obtained.

Sources & evidence

ORD record
ord-62de669f3e2f4fb5a653e7df4179aed6
Source dataset
uspto-grants-1995_11
Patent number
US05466820

Reaction notes

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