4-(4-Fluorobenzoyl)benzyl bromide → HCID 18918879, compound

HRID 1291323Notes

Reaction equation

HRID 1291323 reaction equation
[K].[SH:2][C:3]1[N:4]([CH3:13])[C:5](=[O:12])[C:6]2[CH:11]=[N:10][NH:9][C:7]=2[N:8]=1.[F:14][C:15]1[CH:30]=[CH:29][C:18]([C:19]([C:21]2[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=2)=[O:20])=[CH:17][CH:16]=1>CN(C=O)C.O>[F:14][C:15]1[CH:16]=[CH:17][C:18]([C:19]([C:21]2[CH:28]=[CH:27][C:24]([CH2:25][S:2][C:3]3[N:4]([CH3:13])[C:5](=[O:12])[C:6]4[CH:11]=[N:10][NH:9][C:7]=4[N:8]=3)=[CH:23][CH:22]=2)=[O:20])=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 47290134-(4-Fluorobenzoyl)benzyl bromideHCID 178481671HCID 178481671, compound

Product 1

HCID 18918879HCID 18918879, compoundYield 82.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 6-mercapto-5-methyl-1H-pyrazolo-[3,4-d]pyrimidin-4(5H)-one potassium (1.0 g) in DMF (20 ml) was added 4-(4-fluorobenzoyl)benzyl bromide (1.745 g) and the mixture was stirred at room temperature for 1 hour. This reaction mixture was poured in water and the resulting crystals were collected by filtration, rinsed with water and methanol to provide the title compound as colorless solid (1.467 g).

Workup

  1. filtrationthe resulting crystals were collected by filtration
  2. washrinsed with water and methanol

Sources & evidence

ORD record
ord-8ffe5f2ccac944e78ee45c0cd7b8d65f
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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