反应详情

To a solution of 2-[4-(4-acetoxybenzoyl) benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-one (3.51 g) in THF (20 ml) was added 1N-sodium hydroxide/water (10 ml) and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was concentrated, the residue was dissolved in water, and 1N-hydrochloric acid was added. The resulting crystals were collected by filtration, rinsed with water, and dried to provide the title compound as colorless solid (3.22 g).

1. concentrationThis reaction mixture was concentrated
2. dissolutionthe residue was dissolved in water
3. addition1N-hydrochloric acid was added
4. filtrationThe resulting crystals were collected by filtration
5. washrinsed with water
6. customdried