反应详情

To a suspension of 3,5-dimethyl-2-[4-[4-(2-hydroxyethoxy)benzoyl]benzylthio]-4(3H)-quinazolinone (651 mg) in carbon tetrachloride (15 ml) was added triphenylphosphine (476 mg) and the mixture was refluxed for 40 hours. This reaction mixture was concentrated and the residue was purified by silica gel column chromatography (dichloromethane) and recrystallized from ethyl acetate to provide the title compound as colorless solid (391 mg).

1. temperaturethe mixture was refluxed for 40 hours
2. concentrationThis reaction mixture was concentrated
3. customthe residue was purified by silica gel column chromatography (dichloromethane)
4. customrecrystallized from ethyl acetate