Acetic Anhydride → HCID 69961015, compound

HRID 1291400Notes

Reaction equation

HRID 1291400 reaction equation
[CH3:1][C:2]1[N:11]([CH3:12])[C:10](=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[CH3:14])[N:3]=1.[Cl:15][C:16]1[CH:31]=[CH:30][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=2)=[O:21])=[CH:18][CH:17]=1.C(OC(=O)C)(=O)C>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH:26]=[CH:1][C:2]3[N:11]([CH3:12])[C:10](=[O:13])[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][C:8]=4[CH3:14])[N:3]=3)=[CH:24][CH:23]=2)=[O:21])=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 12925059HCID 12925059, compoundHCID 18919240HCID 18919240, compound

Product 1

HCID 69961015HCID 69961015, compoundYield 60.8%

Conditions

Temperature
140 °C

Procedure

To a mixture of 2,3,5-trimethyl-4(3H)-quinazolinone (376 mg) and 4-(4-chlorobenzoyl)benzaldehyde (1.1 g) was added acetic anhydride (0.5 ml) and the mixture was stirred at 140° C. for 2 hours. This reaction mixture was concentrated and the residue was washed with diethyl ether and dried to provide 504 mg of yellow powder.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-e3acc451853247728dcc00cd2826974c
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

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