反应详情

7-[4-(4-Fluorobenzoyl)benzyl]-5-methyl-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one (775 mg) was dissolved in a mixture of DME (100 ml), ethyl acetate (100 ml) and methanol (80 ml). After addition of acetic acid (2.5 ml), Raney nickel was added. After confirming disapperance of the starting compound, the catalyst was filtered off. The solvent was then distilled off under reduced pressure. The residue was pulverized with ether, and the crystalline powder was collected by filtration, rinsed with ether, and dried to provide the title compound (529 mg).

1. additionwas added
2. filtrationthe catalyst was filtered off
3. distillationThe solvent was then distilled off under reduced pressure
4. filtrationthe crystalline powder was collected by filtration
5. washrinsed with ether
6. customdried