Water → HCID 11796738, compound

HRID 1291562Notes

Reaction equation

HRID 1291562 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=3)[N:12]=[C:11]([CH:24]([F:26])[F:25])[CH:10]=2)=[CH:5][CH:4]=1.ClC1C=C(C=CC=1)C(OO)=[O:32].[OH2:38]>C(Cl)Cl>[CH3:1][S:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:13]([C:14]3[CH:15]=[CH:16][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:18][CH:19]=3)[N:12]=[C:11]([CH:24]([F:26])[F:25])[CH:10]=2)=[CH:7][CH:8]=1)(=[O:32])=[O:38]

Participants

5

Reactant 3

HCID 962WaterHCID 70297m-Chloroperbenzoic acidHCID 10294097HCID 10294097, compound

Product 1

HCID 11796738HCID 11796738, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

4-[5-(4-[Methylthio]phenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (0.5 g, 1.27 mmol) was dissolved in methylene chloride (30 mL) and cooled to 0° C. To this solution was added m-chloroperoxybenzoic acid (MCPBA) (60%, 0.77 g, 2.7 mmol) and the solution was allowed to warm to room temperature while stirring for 18 hours. A solution of Na2 S2O5 (2 g) in H2O (25 mL) was added to the reaction mixture and the solution stirred vigorously for 0.5 hour. The layers were separated and the organic layer was washed with saturated NaHCO3 (30 mL) and brine (30 mL), dried over Na2SO4 and concentrated to yield 4-[5-(4-[methylsulfonyl] phenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide as a white solid, 0.22 g, 40%, mp=209°-210° C.

Workup

  1. temperatureto warm to room temperature
  2. stirringthe solution stirred vigorously for 0.5 hour
  3. customThe layers were separated
  4. washthe organic layer was washed with saturated NaHCO3 (30 mL) and brine (30 mL)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-ed334e3115ed4b20aafcf9e9e3129571
Source dataset
uspto-grants-1998_05
Patent number
US05753688

Reaction notes

Loading…