反应详情

Ethyl difluoroacetate (2.30 g, 18.5 mmol) was placed in a 100 mL round bottom flask and dissolved in THF (25 mL). To the stirred solution was added 25 weight % sodium -methoxide (4.90 g, 22.6 mmol) followed by 4'-morpholinoacetophenone (3.45 g, 16.8 mmol). The reaction was stirred at room temperature overnight (15.8 hours), then treated with 3N HCl (13 mL). The reaction was extracted with ethyl acetate (20 mL), washed with brine (20 mL), dried over MgSO4, and concentrated in vacuo to give a green solid (4.36 g) which was recrystallized from methylene chloride/isooctane to give the diketone as a yellow solid (3.27 g, mp 102°-3° C., 69%). 1H NMR (CDCl3) 300 MHz 15.80 (br s, 1H), 7.86 (d, J=9.1 Hz, 2H), 6.90 (d, J=9.l1 Hz, 2H), 6. 46 (s, 1H), 5.99 (t, J=54.4 Hz, 1H), 3.84 (m,4 H), 3.36 (m,4H) ; 19F NMR (CDCl3) 300 MHz: -126.75 (d); M+ 283.

1. extractionThe reaction was extracted with ethyl acetate (20 mL)
2. washwashed with brine (20 mL)
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo