反应详情

To a solution of 1-tert-butyl-5-cyclopropyl-1H-pyrazole-4-carboxylic acid methyl ester (921 mg, 4.14 mmol) in methanol (15 mL) and water (15 mL) was added LiOH (119 mg, 4.97 mmol). The reaction mixture was stirred at reflux overnight, and then the solution was concentrated under reduced pressure to remove the methanol. The residue was diluted with water and the solution was acidified to pH 2 with concentrated HCl. The resulting mixture was then extracted with ethyl acetate three times. The combined organic extracts were concentrated in vacuo to give 1-tert-butyl-5-cyclopropyl-1H-pyrazole-4-carboxylic acid (789 mg, 92%), which was used without further purification.

1. temperatureat reflux overnight
2. concentrationthe solution was concentrated under reduced pressure
3. customto remove the methanol
4. additionThe residue was diluted with water
5. extractionThe resulting mixture was then extracted with ethyl acetate three times
6. concentrationThe combined organic extracts were concentrated in vacuo