Hydrochloric Acid → HCID 14585923, compound

HRID 1291729Notes

Reaction equation

HRID 1291729 reaction equation
[CH2:1]([N:5](C(OC(C)(C)C)=O)[CH2:6][CH2:7][CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18](C(OC(C)(C)C)=O)[CH2:19][CH2:20][CH2:21][N:22]([CH2:30][CH:31]=[C:32]=[CH2:33])C(OC(C)(C)C)=O)[CH:2]=[C:3]=[CH2:4].Cl>CCO.CCOCC>[CH2:30]([NH:22][CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7][CH2:6][NH:5][CH2:1][CH:2]=[C:3]=[CH2:4])[CH:31]=[C:32]=[CH2:33]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14585922HCID 14585922, compound

Product 1

HCID 14585923HCID 14585923, compoundYield 92.6%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

Dissolve 0.5 gm of the product of Step H in 2 ml of EtOH and while stirring treat the mixture with 10 ml of 2N HCl in Et2O. Stir the resulting mixture overnight, filter and dry the solids (in vacuo) to obtain 0.22 gm of the desired product, mp 283°-284° C. dec. Using the abbreviated form for naming the compounds embraced by formula I, it is to be noted that the following specific compounds are readily prepared by applying the foregoing described techniques and procedures and by applying known prior art principles to achieve the necessary modifications:

Workup

  1. stirringStir the resulting mixture overnight
  2. filtrationfilter
  3. customdry the solids (in vacuo)

Sources & evidence

ORD record
ord-bd00dfa6165d4c3c9df4881e8754686b
Source dataset
uspto-grants-1998_05
Patent number
US05753714

Reaction notes

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