Acetic Anhydride → HCID 54190602, compound

HRID 1291734Notes

Reaction equation

HRID 1291734 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:17])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:17][C:18](=[O:20])[CH3:19])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([I:16])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18920666HCID 18920666, compound

Product 1

HCID 54190602HCID 54190602, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1 ,2-di(p-bromophenyl)-hydroxyethane (17.8 g, 0.05 mol), potassium iodide (165 g), copper (I) iodide (95 g) and hexamethylphosphoramide (200 mL) was stirred at 150-160° C. for 48 h and then cooled. Work-up was as described in Example IV to provide a light yellow solid (10 g), which was the expected 1,2-di(p-iodophenyl)-1-hydroxyethane. A portion of this compound (7.2 g, 0.016 mol), acetic anhydride (16 mL), pyridine (16 mL) were heated at 60° C. for 30 min, followed by standing for 2 days. The resulting solution was worked up as in Example IlIl to provide an oil which solidified upon standing. The solid was crystallized from hexanes to provide the title compound as a light yellow solid (4.3 g).

Workup

  1. customto provide an oil which
  2. customThe solid was crystallized from hexanes

Sources & evidence

ORD record
ord-4f3a1ab3940b40c2b87ff8c166261605
Source dataset
uspto-grants-1998_05
Patent number
US05753757

Reaction notes

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