HCID 18917760, compound → HCID 18917961, compound

HRID 1291768Notes

Reaction equation

HRID 1291768 reaction equation
C([O:8][C:9](=[O:20])[CH2:10][NH:11][C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[O:17]1[CH2:18][CH2:19][N:14]([C:12]([NH:11][CH2:10][C:9]([OH:20])=[O:8])=[O:13])[CH2:15][CH2:16]1

Participants

4

Reactant 1

HCID 18917760HCID 18917760, compound

Product 1

HCID 18917961HCID 18917961, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Analogously to Example 7a), 4.8 g (18.3 mmol) of N-morpholinocarbonyl-glycine-benzyl ester in 100 ml of ethyl acetate are hydrogenated with 1 g of palladium (10%) on carbon to yield the title compound: 1H-NMR (300 MHz, CDCl3): 3.88 (s, 2H), 3.64 (s, 4H), 3.50 (s, 2H), 3.35 (s, 4H).

Sources & evidence

ORD record
ord-250bfbce3e5e466eb64b76db7ec387a5
Source dataset
uspto-grants-1998_05
Patent number
US05753652

Reaction notes

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