反应详情

The product from step (iii) (0.52 g) in 1 molar hydrochloric acid (11.9 ml) was heated at 95° C. for 5 hours. The solvent was evaporated and the residue, on drying over potassium hydroxide in vacuo gave 4-amino-1-(4-pyridyl)piperidine trihydrochloride hydrate, 0.70 g as a light brown solid: m.p. >300° C.; NMR (d6DMSO) δ 8.28(4H,m), 7.22(2H,d), 4.27(2H,bd), 3.5 to 3.15(3H+H2O), 2.09(2H,m), 1.59(2H,dq); m/e 178(M+H)+ ; calculated for C10 H15N3. 3HCl. 0.75 H2O: C, 40.0; H, 6.5; N, 14.0. found: C, 40.4; H, 6.3; N, 13.5%.

1. customThe solvent was evaporated
2. dry with materialthe residue, on drying over potassium hydroxide in vacuo