Pyridine → HCID 53661555, compound

HRID 1291958Notes

Reaction equation

HRID 1291958 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH:7]=1)[CH3:2].S(Cl)([Cl:17])=O.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([O:3][CH2:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([Cl:17])=[O:11])=[CH:8][CH:7]=1)[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 13651690HCID 13651690, compound

Product 1

HCID 53661555HCID 53661555, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-(Ethoxyethyl)benzoic acid (1.4 g, 7.2 mmol) was mixed with thionyl chloride (1.3 g, 10.8 mmol), pyridine (0.1 ml) and toluene (4 ml), followed by reacting them at 80° C. for 2 hours, distilling superfluous thionyl chloride and toluene under reduced pressure, to obtain raw 4-(ethoxy-ethyl)benzoyl chloride.

Workup

  1. customat 80° C.
  2. customfor 2 hours
  3. distillationdistilling superfluous thionyl chloride and toluene under reduced pressure

Sources & evidence

ORD record
ord-e45c29119e5f460d8dfb66e8c3e02a51
Source dataset
uspto-grants-1998_05
Patent number
US05755994

Reaction notes

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