HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → Methyl 4-(N-t-butyloxycarbonyl-4-piperidinyloxy)-5-fluoro-2-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | Methyl 5-fluoro-4-hydroxy-2-methoxybenzoate | HCID 18914108 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 4-(N-t-butyloxycarbonyl-4-piperidinyloxy)-5-fluoro-2-methoxybenzoate | HCID 18914097 | — |
Reaction Steps
Methyl 5-fluoro-4-hydroxy-2-methoxybenzoate from step 4 above was coupled to N-Boc-4-piperidinol using Mitsunobu conditions as given in step 4 of Example 1. Methyl 4-(N-t-butyloxycarbonyl-4-piperidinyloxy)-5-fluoro-2-methoxybenzoate was obtained as a gum (TLC Rf = 0.19 (3:7 EtOAc:hexanes); HPLC (method A) retention time= 9.9 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756497 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-997cc02a98d944189e6c08e5d8e1880f |
| Source note | uspto-grants-1998_05 |