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HRID1292039

反应详情

EQUATION

反应方程式

HRID 1292039 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N1CCC(O)CC1
HCID643502

n-boc-4-hydroxypiperidine

C10H19NO3

结构：COC(=O)c1cc(F)c(O)cc1OC
HCID18914108

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(F)c(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1OC
HCID18914097

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Methyl 5-fluoro-4-hydroxy-2-methoxybenzoate from step 4 above was coupled to N-Boc-4-piperidinol using Mitsunobu conditions as given in step 4 of Example 1. Methyl 4-(N-t-butyloxycarbonyl-4-piperidinyloxy)-5-fluoro-2-methoxybenzoate was obtained as a gum (TLC Rf = 0.19 (3:7 EtOAc:hexanes); HPLC (method A) retention time= 9.9 min).