Dichloromethane → HCID 18914110, compound

HRID 1292047Notes

Reaction equation

HRID 1292047 reaction equation
[CH3:1][C:2]1[N:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[C:3]=1[C:4](OC)=[O:5].C(Cl)Cl>CO>[OH:5][CH2:4][C:3]1[C:2]([CH3:1])=[N:11][CH:10]=[CH:9][C:8]=1[C:12]([F:15])([F:13])[F:14]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 18914102HCID 18914102, compound

Product 1

HCID 18914110HCID 18914110, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-methyl-4-trifluoromethylnicotinate was reduced using the procedure as given in step 1 of Example 3. 3-Hydroxymethyl-2-methyl-4-trifluoromethylpyridine was obtained as a pale yellow waxy solid(TLC Rf = 0.31 (97:3 CH2Cl2 :MeOH)).

Sources & evidence

ORD record
ord-e8469d2f2471488cb2fd39930724a0ed
Source dataset
uspto-grants-1998_05
Patent number
US05756497

Reaction notes

Loading…