HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → Pyridine, 3-(chloromethyl)-2-methyl-4-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | HCID 18914110 | HCID 18914110 | — |
| Product | Pyridine, 3-(chloromethyl)-2-methyl-4-(trifluoromethyl)- | HCID 18914101 | — |
Reaction Steps
3-Hydroxymethyl-2-methyl-4-trifluoromethylpyridine from step 1 above was converted to the chloride using the procedure given in step 2 of Example 3. The crude 3-chloromethyl-2-methyl-4-trifluoromethylpyridine was purified by pressurized silica gel column chromatography using 95:5 hexane:EtOAc as eluant. 3-Chloromethyl-2-methyl-4-trifluoromethylpyridine was obtained as a white solid (TLC Rf = 0.45 (9:1 hexane:EtOAc)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756497 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-07a4b52bdd124f698847716a24349dc3 |
| Source note | uspto-grants-1998_05 |