Chloride → HCID 18914101, compound

HRID 1292048Notes

Reaction equation

HRID 1292048 reaction equation
O[CH2:2][C:3]1[C:4]([CH3:13])=[N:5][CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10].[Cl-:14]>>[Cl:14][CH2:2][C:3]1[C:4]([CH3:13])=[N:5][CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10]

Participants

3

Reactant 2

HCID 312ChlorideHCID 18914110HCID 18914110, compound

Product 1

HCID 18914101HCID 18914101, compound

Procedure

3-Hydroxymethyl-2-methyl-4-trifluoromethylpyridine from step 1 above was converted to the chloride using the procedure given in step 2 of Example 3. The crude 3-chloromethyl-2-methyl-4-trifluoromethylpyridine was purified by pressurized silica gel column chromatography using 95:5 hexane:EtOAc as eluant. 3-Chloromethyl-2-methyl-4-trifluoromethylpyridine was obtained as a white solid (TLC Rf = 0.45 (9:1 hexane:EtOAc)).

Workup

  1. customThe crude 3-chloromethyl-2-methyl-4-trifluoromethylpyridine was purified by pressurized silica gel column chromatography

Sources & evidence

ORD record
ord-07a4b52bdd124f698847716a24349dc3
Source dataset
uspto-grants-1998_05
Patent number
US05756497

Reaction notes

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