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Compound II (2.62 g, 10.3 mmol) and phosphorus oxychloride (3.18 mL, 34 mmoL) were combined and heated under reflux for 2 days. After cooling to room temperature, the reaction mixture was poured into ice water and made basic with aqueous sodium hydroxide (pH>7). The product was collected by filtration and dried in a vacuum oven overnight to give 2.82 g (100%) of 1-chloro-4-trifluoromethylpyridazino[4,5-b]indolizine (III)

1. temperatureheated
2. temperatureunder reflux for 2 days
3. filtrationThe product was collected by filtration
4. customdried in a vacuum oven overnight