反应详情

To 1-isobutylpiperazine dihydrochloride (69.5 g) was added 10% aqueous sodium hydroxide solution (100 ml) and then the resulting mixture was extracted with ether. After the extract was concentrated, the residue was distilled under reduced pressure (bp: 172° to 174° C./5 mmHg), thereby yielding 43.7 g of the aimed compound.

1. extractionthe resulting mixture was extracted with ether
2. concentrationAfter the extract was concentrated
3. distillationthe residue was distilled under reduced pressure (bp: 172° to 174° C./5 mmHg)