1-Isobutylpiperazine dihydrochloride → 1-(2-Methylpropyl)piperazine

HRID 1292098Notes

Reaction equation

HRID 1292098 reaction equation
Cl.Cl.[CH2:3]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH:4]([CH3:6])[CH3:5]>[OH-].[Na+]>[CH2:3]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH:4]([CH3:6])[CH3:5]

Participants

3

Reactant 1

HCID 27593881-Isobutylpiperazine dihydrochloride

Product 1

HCID 20520521-(2-Methylpropyl)piperazineYield 95.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To 1-isobutylpiperazine dihydrochloride (69.5 g) was added 10% aqueous sodium hydroxide solution (100 ml) and then the resulting mixture was extracted with ether. After the extract was concentrated, the residue was distilled under reduced pressure (bp: 172° to 174° C./5 mmHg), thereby yielding 43.7 g of the aimed compound.

Workup

  1. extractionthe resulting mixture was extracted with ether
  2. concentrationAfter the extract was concentrated
  3. distillationthe residue was distilled under reduced pressure (bp: 172° to 174° C./5 mmHg)

Sources & evidence

ORD record
ord-2f12eb8c0b814d4f932d6a685bf0d32e
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

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