HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isobutylpiperazine dihydrochloride → 1-(2-Methylpropyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isobutylpiperazine dihydrochloride | HCID 2759388 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-(2-Methylpropyl)piperazine | HCID 2052052 | 95.1% |
Reaction Steps
To 1-isobutylpiperazine dihydrochloride (69.5 g) was added 10% aqueous sodium hydroxide solution (100 ml) and then the resulting mixture was extracted with ether. After the extract was concentrated, the residue was distilled under reduced pressure (bp: 172° to 174° C./5 mmHg), thereby yielding 43.7 g of the aimed compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756505 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-2f12eb8c0b814d4f932d6a685bf0d32e |
| Source note | uspto-grants-1998_05 |