4-(Bromomethyl)-1,2-difluorobenzene → HCID 18914212, compound

HRID 1292116Notes

Reaction equation

HRID 1292116 reaction equation
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22].[F:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][C:32]=1[F:33])[CH2:28]Br>>[F:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][C:32]=1[F:33])[CH2:28][O:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:12][CH2:13]2)=[O:7])=[CH:4][C:3]=1[CH2:20][CH:21]([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 5814364-(Bromomethyl)-1,2-difluorobenzeneHCID 18914218HCID 18914218, compound

Product 1

HCID 18914212HCID 18914212, compoundYield 96.5%

Procedure

As in the case of Example 18, 1-(4-hydroxy-3-isobutylbenzoyl)-4-isobutylpiperazine (1.24 g) was benzylated with 3,4-difluorobenzyl bromide (1.60 g), thereby yielding 1.67 g of the aimed compound.

Sources & evidence

ORD record
ord-f442a79374e1436e9f42d509556c73fc
Source dataset
uspto-grants-1998_05
Patent number
US05756505

Reaction notes

Loading…