HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic Acid → O-2-[Z-5-fluoro-2-methyl-1-(4-pyridyl)methylene-1H-inden-3-yl]ethyl hydroxylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic Acid | HCID 760 | — |
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
| Reactant | HCID 178479002 | HCID 178479002 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | O-2-[Z-5-fluoro-2-methyl-1-(4-pyridyl)methylene-1H-inden-3-yl]ethyl hydroxylamine | HCID 86752651 | — |
Reaction Steps
The title compound is prepared by Grignard reaction of 5-fluoro-2-methylindanone with 4-pyridylmethylmagnesium chloride to provide the intermediate adduct which is treated with glyoxalic acid under dehydrating aldol conditions to provide Z-5-fluoro-2-methyl-1-(4-pyridyl)methylene-1H-inden-3-yl!acetic acid which is converted to the hydroxylamine by the procedures described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05756531 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-8305cd1fa12b4cd891197daf8e51a66a |
| Source note | uspto-grants-1998_05 |