反应详情

The title compound is prepared by Grignard reaction of 5-fluoro-2-methylindanone with 4-pyridylmethylmagnesium chloride to provide the intermediate adduct which is treated with glyoxalic acid under dehydrating aldol conditions to provide Z-5-fluoro-2-methyl-1-(4-pyridyl)methylene-1H-inden-3-yl!acetic acid which is converted to the hydroxylamine by the procedures described in Example 1.

1. customto provide the intermediate adduct which
2. customto provide Z-5-fluoro-2-methyl-1-(4-pyridyl)methylene-1H-inden-3-yl