Aluminium lithium hydride → HCID 22857203, compound

HRID 129237Notes

Reaction equation

HRID 129237 reaction equation
[CH2:1]([N:3]1[C@@H:8]2[CH2:9][C:10]3[C:11]4[C:16]([NH:17][CH:18]=3)=[CH:15][CH:14]=[C:13]([O:19][CH3:20])[C:12]=4[C@@:7]2([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:6][CH2:5][C:4]1=O)[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH2:1]([N:3]1[C@@H:8]2[CH2:9][C:10]3[C:11]4[C:16]([NH:17][CH:18]=3)=[CH:15][CH:14]=[C:13]([O:19][CH3:20])[C:12]=4[C@@:7]2([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[O:6][CH:5]=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22857204HCID 22857204, compound

Product 1

HCID 22857203HCID 22857203, compoundYield 12%

Procedure

Trans-7-ethyl-4,6,6a,8,9,10a-hexahydro-1-methoxy-10a-phenyl-7H-indolo[3,4-gh][1.4]benzoxazin-8-one (664 mg, 1.83 mmol) was reduced with LAH. The residue thus obtained was subjected to a silica gel column chromatography, eluting with n-hexane-ethyl acetate (3:1), to afford 74 mg (12%) of the title compound as a crude crystalline product (m.p.194-196 dec.)

Workup

  1. customThe residue thus obtained
  2. washeluting with n-hexane-ethyl acetate (3:1)

Sources & evidence

ORD record
ord-20a387e021e8472b80f47dca0b8f3046
Source dataset
uspto-grants-1995_11
Patent number
US05466689

Reaction notes

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