反应详情

To a stirred suspension of 2-(1H-indol-3-yl)ethylamine (2.0 g in 20 mL of dry tetrahydrofuran) was added N-carbethoxyphthalimide (2.85 g) and the mixture heated to reflux on an oil bath. After 48 hours the reaction was cooled to room temperature, filtered and the filtrate concentrated in vacuo. The resulting solid was suspended in a mixture of hexane/methylene chloride (2.5:1) and filtered. Purification of the collected solids by flash chromatography on silica gel (methylene chloride:methanol, 97:3) gave the title compound (3.1 g).

1. temperaturethe mixture heated
2. temperatureto reflux on an oil bath
3. filtrationfiltered
4. concentrationthe filtrate concentrated in vacuo
5. additionThe resulting solid was suspended in a mixture of hexane/methylene chloride (2.5:1)
6. filtrationfiltered
7. customPurification of the collected solids by flash chromatography on silica gel (methylene chloride:methanol, 97:3)