反应详情

温度

0 °C

To a solution of 2-[2-(1H-indol-3-yl)-ethyl]-isoindole-1,3-dione (1.0 g in a mixture of 10 mL dry tetrahydrofuran and 10 mL dry chloroform) at 0° C. was added pyridinium bromide perbromide (1.14 g) and the reaction stirred at 0° C. After 50 minutes, the reaction was quenched by the addition of saturated sodium bicarbonate and extracted with ethyl acetate. The organic portion was washed with saturated sodium bicarbonate (3×) and 0.3M sodium bisulfate (3×) then dried over magnesium sulfate. Purification of the concentrate by flash chromatography on silica gel (hexane:ethyl acetate, 3:1) gave the title compound (1.2 g).

1. customthe reaction was quenched by the addition of saturated sodium bicarbonate
2. extractionextracted with ethyl acetate
3. washThe organic portion was washed with saturated sodium bicarbonate (3×) and 0.3M sodium bisulfate (3×)
4. dry with materialthen dried over magnesium sulfate
5. customPurification of the
6. concentrationconcentrate by flash chromatography on silica gel (hexane:ethyl acetate, 3:1)