Sodium Hydroxide → HCID 15170859, compound

HRID 1292423Notes

Reaction equation

HRID 1292423 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH3:10])[C:6](=[O:11])[N:5]([CH2:12][CH2:13][CH3:14])[C:4](=[O:15])[C:3]=1[NH:16][C:17](=O)/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1.[OH-].[Na+]>O1CCOCC1>[Cl:26][C:23]1[CH:24]=[CH:25][C:20](/[CH:19]=[CH:18]/[C:17]2[NH:16][C:3]3[C:4](=[O:15])[N:5]([CH2:12][CH2:13][CH3:14])[C:6](=[O:11])[N:7]([CH2:8][CH2:9][CH3:10])[C:2]=3[N:1]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18915204HCID 18915204, compound

Product 1

HCID 15170859HCID 15170859, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To Compound c (7.84 g, 20.1 mmol) were added 100 ml of dioxane and 100 ml of 2N aqueous solution of sodium hydroxide, followed by heating under reflux for 10 minutes. After cooling, the mixture was neutralized, and deposited crystals were collected by filtration and recrystallized from dioxane-water to give 6.83 g (yield: 91%) of Compound 5 as white crystals.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 10 minutes
  3. temperatureAfter cooling
  4. filtrationwere collected by filtration
  5. customrecrystallized from dioxane-water

Sources & evidence

ORD record
ord-551917864d4148229ee2bb385a31e9a6
Source dataset
uspto-grants-1998_05
Patent number
US05756735

Reaction notes

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