3-(Pyrrolidin-1-ylmethyl)morpholine → 4-(3-Oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride

HRID 1292437Notes

Reaction equation

HRID 1292437 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:13]=[C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]([C:23]([Cl:25])=[O:24])[CH2:15]1>C(N(CC)CC)C>[ClH:25].[O:13]=[C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]([C:23]([N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH:7]2[CH2:6][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:24])[CH2:15]1

Participants

4

Reactant 2

HCID 189150613-(Pyrrolidin-1-ylmethyl)morpholineHCID 218205193-Oxoindan-1-carbonyl chloride

Product 1

HCID 189151594-(3-Oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochlorideYield 21%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 0.86 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 1.96 ml of triethylamine and 0.89 g of 3-oxoindan-1-carbonyl chloride, to afford 0.35 g of the title compound, melting at 260°-265° C. (dec.).

Sources & evidence

ORD record
ord-44558aed55e24a098b6334ba4b786225
Source dataset
uspto-grants-1998_05
Patent number
US05756730

Reaction notes

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