HCID 18915111, compound → HCID 18915181, compound

HRID 1292441Notes

Reaction equation

HRID 1292441 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]1[CH2:10][O:9][CH2:8][CH2:7][NH:6]1)[CH3:3].[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH:17]([C:21](Cl)=[O:22])[CH2:16][C:15]2=[O:24]>C(N(CC)CC)C>[ClH:11].[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH:17]([C:21]([N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH:5]1[CH2:4][N:2]([CH3:3])[CH3:1])=[O:22])[CH2:16][C:15]2=[O:24]

Participants

4

Reactant 2

HCID 18915111HCID 18915111, compoundHCID 18915134N,N-Dimethyl-3-morpholinemethanamine

Product 1

HCID 18915181HCID 18915181, compoundYield 122.7%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 0.90 g of 3-dimethylaminomethylmorpholine, 2.3 ml of triethylamine and 1.03 g of 5-chloro-3-oxoindan-1-carbonyl chloride, to afford 1.03 g of the title compound, melting at 230°-240° C.

Sources & evidence

ORD record
ord-7c3f824ad66a4198bf5eec7d97af5a80
Source dataset
uspto-grants-1998_05
Patent number
US05756730

Reaction notes

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