3-(Pyrrolidin-1-ylmethyl)thiomorpholine → HCID 18915117, compound

HRID 1292444Notes

Reaction equation

HRID 1292444 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[CH:19]([C:23](Cl)=[O:24])[CH2:18][C:17]2=[O:26]>C(N(CC)CC)C>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[CH:19]([C:23]([N:8]1[CH2:9][CH2:10][S:11][CH2:12][CH:7]1[CH2:6][N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:24])[CH2:18][C:17]2=[O:26]

Participants

4

Reactant 2

HCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholineHCID 18915111HCID 18915111, compound

Product 1

HCID 18915117HCID 18915117, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 3.7 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 3.42 ml of triethylamine and 4.56 g of 5-chloro-3-oxoindan-1-carbonyl chloride, to afford 2.8 g of the title compound, melting at 200°-205° C. (dec.).

Sources & evidence

ORD record
ord-ef3aca71e34945039dece257b549d3ff
Source dataset
uspto-grants-1998_05
Patent number
US05756730

Reaction notes

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