5,6-Dichloro-3-oxoindan-1-carbonyl chloride → 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(piperidinomethyl)thiomorpholine hydrochloride

HRID 1292447Notes

Reaction equation

HRID 1292447 reaction equation
[N:1]1([CH2:7][CH:8]2[CH2:13][S:12][CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[Cl:24])[CH:20]([C:25](Cl)=[O:26])[CH2:19][C:18]2=[O:28]>C(N(CC)CC)C>[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[Cl:24])[CH:20]([C:25]([N:9]1[CH2:10][CH2:11][S:12][CH2:13][CH:8]1[CH2:7][N:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)=[O:26])[CH2:19][C:18]2=[O:28]

Participants

4

Reactant 2

HCID 151324075,6-Dichloro-3-oxoindan-1-carbonyl chlorideHCID 189151213-(Piperidinomethyl)thiomorpholine

Product 1

HCID 189149884-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(piperidinomethyl)thiomorpholine hydrochlorideYield 34.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 0.9 g of 3-(piperidinomethyl)thiomorpholine, 1.0 g of triethylamine and 1.5 g of 5.6-dichloro-3-oxoindan-1-carbonyl chloride, to afford 0.45 g of the title compound, melting at 146°-155° C.

Sources & evidence

ORD record
ord-67ea9e41338946939ed00dc9c64d5585
Source dataset
uspto-grants-1998_05
Patent number
US05756730

Reaction notes

Loading…