Hydrochloric Acid → HCID 18915088, compound

HRID 1292454Notes

Reaction equation

HRID 1292454 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:13]>O1CCOCC1>[ClH:13].[ClH:13].[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholine

Product 1

HCID 18915088HCID 18915088, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 260 mg of 3-(pyrrolidin-1-ylmethyl)thiomorpholine and 5 ml of 1,4-dioxane was treated with 150 μl of 4N 1,4-dioxane solution of hydrogen chloride. The solvent was evaporated under reduced pressure to yield 354 mg (98%) of 3-(pyrrolidin-1-ylmethyl)thiomorpholine dihydrochloride, melting at 218°-220° C.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e5ed361305e2432f8d38374bfca6492d
Source dataset
uspto-grants-1998_05
Patent number
US05756730

Reaction notes

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