反应详情

温度

75 °C

To a suspension of the ester 19 (0.115 g, 0.304 mmol) in 75% aqueous methanol (3 mL) was added one pellet of potassium hydroxide (0.12 g), The mixture was stirred at 75° C. for 1 h during which time the material dissolved. The solution was cooled to room temperature, acidified with 1N aqueous hydrochloric acid, and then extracted with 80% ethyl acetate/hexane. The combined organic layers were dried over anhydrous MgSO4, filtered, and concentrated to afford the desired acid 20 as a white powder (0.11 g, 99%): m.p. 204°-206° C. The structure of the product was also confirmed using IR, 1H NMR and mass spectroscopy.

1. dissolutiondissolved
2. temperatureThe solution was cooled to room temperature
3. extractionextracted with 80% ethyl acetate/hexane
4. dry with materialThe combined organic layers were dried over anhydrous MgSO4
5. filtrationfiltered
6. concentrationconcentrated