HCID 18915811, compound → Benzoic acid, 2-fluoro-4-hydroxy-, 6-ethoxy-1-(trifluoromethyl)hexyl ester

Participants

Reaction Steps

An autoclave was charged with 1 g of 4-benzyloxy-2-fluoro-1-(6-ethoxy-1-trifluoromethylhexyloxycarbonyl)-benzene, 15 ml of ethyl acetate and 0.5 g of a 15 wt % Pd/carbon catalyst, the atmosphere in the autoclave was replaced with nitrogen and then with hydrogen, and the mixture was continuously stirred at room temperature until the hydrogen absorption terminated. After the reaction, the catalyst was filtered off. The ethyl acetate was distilled off to give a crude 4-hydroxy-2-fluoro-1-(6-ethoxy-1-trifluoromethyl-hexyloxycarbonyl)benzene.

Provenance & Evidence