HCID 18915811, compound → Benzoic acid, 2-fluoro-4-hydroxy-, 6-ethoxy-1-(trifluoromethyl)hexyl ester

HRID 1292582Notes

Reaction equation

HRID 1292582 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([O:17][CH:18]([C:27]([F:30])([F:29])[F:28])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][CH3:26])=[O:16])=[C:11]([F:31])[CH:10]=1)C1C=CC=CC=1.[H][H]>[Pd].[C].C(OCC)(=O)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([O:17][CH:18]([C:27]([F:28])([F:29])[F:30])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][CH2:25][CH3:26])=[O:16])=[C:11]([F:31])[CH:10]=1

Participants

5

Reactant 2

HCID 18915811HCID 18915811, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 11013593Benzoic acid, 2-fluoro-4-hydroxy-, 6-ethoxy-1-(trifluoromethyl)hexyl ester

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

An autoclave was charged with 1 g of 4-benzyloxy-2-fluoro-1-(6-ethoxy-1-trifluoromethylhexyloxycarbonyl)-benzene, 15 ml of ethyl acetate and 0.5 g of a 15 wt % Pd/carbon catalyst, the atmosphere in the autoclave was replaced with nitrogen and then with hydrogen, and the mixture was continuously stirred at room temperature until the hydrogen absorption terminated. After the reaction, the catalyst was filtered off. The ethyl acetate was distilled off to give a crude 4-hydroxy-2-fluoro-1-(6-ethoxy-1-trifluoromethyl-hexyloxycarbonyl)benzene.

Workup

  1. customterminated
  2. customAfter the reaction
  3. filtrationthe catalyst was filtered off
  4. distillationThe ethyl acetate was distilled off

Sources & evidence

ORD record
ord-f8ea4d1332124fb3a0b824044fdd9e3a
Source dataset
uspto-grants-1998_05
Patent number
US05756816

Reaction notes

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