Hydrogen Peroxide → HCID 67800504, compound

HRID 1292605Notes

Reaction equation

HRID 1292605 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:31]=[CH:32][CH:33]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:30])[CH2:17][S:18][CH2:19][CH2:20][N:21]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[C:22]([CH3:24])=[O:23])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:34]O>C(O)(=O)C>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:31]=[CH:32][CH:33]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:30])[CH2:17][S:18]([CH2:19][CH2:20][N:21]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[C:22]([CH3:24])=[O:23])=[O:34])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 67799968HCID 67799968, compound

Product 1

HCID 67800504HCID 67800504, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

There was dissolved 1.0 g (0.002 mol) of N-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-[2-(2-thienylacetamino)ethylthio]acetamide in 30 ml of acetic acid and added 0.24 ml (0.0022 mol) of 30 % aqueous solution of hydrogen peroxide under cooling with ice, and the mixture was stirred for 12 hours at room temperature. The solvent was removed under reduced pressure, and then 15 the residue was purified by silica gel column chromatography (chloroform:ethanol=5:1) to give 0.72 g of the titled compound as crystals.

Workup

  1. temperatureunder cooling with ice
  2. customThe solvent was removed under reduced pressure
  3. custom15 the residue was purified by silica gel column chromatography (chloroform:ethanol=5:1)

Sources & evidence

ORD record
ord-551f6b55714c4a76bcf83b0c18fb8104
Source dataset
uspto-grants-1998_05
Patent number
US05756822

Reaction notes

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