Triethylamine → HCID 18660145, compound

HRID 1292677Notes

Reaction equation

HRID 1292677 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:12])([F:11])[F:10].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[CH3:21][S:22]([O:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[C:8](=[O:13])[C:9]([F:10])([F:11])[F:12])(=[O:24])=[O:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 186601442,2,2-Trifluoro-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one

Product 1

HCID 18660145HCID 18660145, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of step A (1.002 g, 5.08 mmol) and triethylamine (0.78 ml, 5.60 mmol) in CH2Cl2 (50 ml) at -25° C. was added methane sulfonyl chloride (0.40 ml, 5.17 mmol) over a period of 5 min and stirring was continued for 1 hr. The solvent was evaporated in vacuo and the residue purified by chromatography (SiO2, 33% EtOAc in hexanes, elution). The title compound was obtained as a colorless oil.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by chromatography (SiO2, 33% EtOAc in hexanes, elution)

Sources & evidence

ORD record
ord-de57cc5c14204dbe86b4d2a7aa4e0de7
Source dataset
uspto-grants-1998_05
Patent number
US05756528

Reaction notes

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