N-(tert-butoxycarbonyl)glycine → HCID 67571715, compound

HRID 1292690Notes

Reaction equation

HRID 1292690 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:13]1([CH2:23][NH:24][CH2:25][C@@H:26]([NH:31][C:32](=[O:48])[CH2:33][C:34]2[N:38]([CH2:39][C:40]3[CH:45]=[CH:44][C:43]([C:46]#[N:47])=[CH:42][CH:41]=3)[CH:37]=[N:36][CH:35]=2)[C@@H:27]([CH3:30])[CH2:28][CH3:29])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1>>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([N:24]([CH2:23][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1)[CH2:25][C@@H:26]([NH:31][C:32](=[O:48])[CH2:33][C:34]1[N:38]([CH2:39][C:40]2[CH:45]=[CH:44][C:43]([C:46]#[N:47])=[CH:42][CH:41]=2)[CH:37]=[N:36][CH:35]=1)[C@@H:27]([CH3:30])[CH2:28][CH3:29])=[O:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 57463855HCID 57463855, compound

Product 1

HCID 67571715HCID 67571715, compound

Procedure

The title compound was prepared using the protocol described in Example 1 step H using N-t-butoxycarbonyl glycine and N-naphth-1-ylmethyl-2(S)-{(1-(4-cyanobenzyl)-1H-imidazol-5-ylacetyl}amino-3(S)-methyl pentanamine from Example 2.

Sources & evidence

ORD record
ord-18bd484a31c74028ab988a9e83b831c2
Source dataset
uspto-grants-1998_05
Patent number
US05756528

Reaction notes

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